Rolapitant and Methotrexate Interaction
Drug interaction information between Rolapitant and Methotrexate.
Rolapitant and Methotrexate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rolapitant and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rolapitant blocks a protein that removes methotrexate from your system, which can cause the drug to build up to unsafe levels.
FDA Label Information
BCRP Substrates with a Narrow Therapeutic Index (e.g., methotrexate, topotecan, or irinotecan) Clinical Impact: Increased plasma concentrations of BCRP substrates (e.g., methotrexate, topotecan, or irinotecan) may result in potential adverse reactions [see Clinical Pharmacology (12.3) ].
Rolapitant Also Interacts With
- Pimozide major
- Thioridazine major
- Rifampin moderate
- Rosuvastatin minor
- Warfarin minor
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Rolapitant + Methotrexate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Rolapitant's 9. In the minor band specifically: Rolapitant has 6 (also Rosuvastatin, Warfarin, Digoxin, Dextromethorphan); Methotrexate has 26 (also Aspirin, Folic Acid, Probenecid, Phenytoin).
What mechanism field is on file for Rolapitant and Methotrexate?
Rolapitant blocks a protein that removes methotrexate from your system, which can cause the drug to build up to unsafe levels.
Rolapitant carries more major-labeled pairs than Methotrexate
SPL source-record counts only. This page's band is minor · classes on file: Rolapitant (NK1 Receptor Antagonist (Antiemetic)); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
Rolapitant has 2 major-labeled pairs vs Methotrexate's 0. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 6 minor · 9 total
- Other minor peers for Rolapitant
- Rosuvastatin
- Warfarin
- Digoxin
- Dextromethorphan
0 major · 12 moderate · 26 minor · 38 total
- Other minor peers for Methotrexate
- Aspirin
- Folic Acid
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.