What the FDA labels say about taking them together
Methotrexate and rolapitant
Rolapitant's FDA label of August 19, 2020 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name rolapitant. The rolapitant label: “Increased plasma concentrations of BCRP substrates may result in potential adverse reactions.”
Check it at the source: the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.); the rolapitant FDA label on DailyMed (effective August 19, 2020, TerSera Therapeutics LLC).
What does the methotrexate label say about rolapitant?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name rolapitant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
What does the rolapitant label say about methotrexate?
Rolapitant label, drug interactionsClinical Impact: Increased plasma concentrations of BCRP substrates (…) may result in potential adverse reactions. Intervention: Monitor for adverse reactions related to the concomitant drug if use of VARUBI cannot be avoided. Use the lowest effective dose of rosuvastatin (see prescribing information for additional information on recommended dosing).
Source: FDA drug label (Varubi), TerSera Therapeutics LLC, effective August 19, 2020 (SPL set a52896cd-4a98-49b8-82db-bf1985a64d97), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methotrexate | Rolapitant | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.158 per tablet 2.5 mg tablet | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once