Risperidone and Valproate Interaction
Drug interaction information between Risperidone and Valproate.
Risperidone and Valproate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Risperidone and Valproate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Risperidone can cause the peak amount of valproate in your blood to increase by a small amount.
FDA Label Information
Valproate Repeated oral doses of risperidone tablets (4 mg once daily) did not affect the pre-dose or average plasma concentrations and exposure (AUC) of valproate (1000 mg/day in three divided doses) compared to placebo (n=21). However, there was a 20% increase in valproate peak plasma concentration (C max) after concomitant administration of risperidone tablets. Dose adjustment for valproate is not recommended.
Risperidone Also Interacts With
- Amitriptyline major
- Carbamazepine major
- Lithium major
- Erythromycin major
- Ranitidine major
Valproate Also Interacts With
- Ranitidine major
- Cimetidine major
- Clarithromycin moderate
- Lidocaine Topical moderate
- Aspirin minor
Frequently Asked Questions
What SPL severity band is on file for Risperidone + Valproate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Valproate has 41 labeled pairs on file vs Risperidone's 20. In the moderate band specifically: Risperidone has 5 (also Methylphenidate, Digoxin, Dexmethylphenidate, Tetrabenazine); Valproate has 3 (also Clarithromycin, Lidocaine Topical).
What mechanism field is on file for Risperidone and Valproate?
Risperidone can cause the peak amount of valproate in your blood to increase by a small amount.
Risperidone carries more major-labeled pairs than Valproate
SPL source-record counts only. This page's band is moderate · classes on file: Risperidone (Atypical Antipsychotic); Valproate (Anticonvulsant / Mood Stabilizer).
Risperidone has 6 major-labeled pairs vs Valproate's 2. This page itself is in the moderate band, not the major band.
6 major · 5 moderate · 9 minor · 20 total
- Other moderate peers for Risperidone
- Methylphenidate
- Digoxin
- Dexmethylphenidate
- Tetrabenazine
2 major · 3 moderate · 36 minor · 41 total
- Other moderate peers for Valproate
- Clarithromycin
- Lidocaine Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.