Risperidone and Methylphenidate Interaction
Drug interaction information between Risperidone and Methylphenidate.
Risperidone and Methylphenidate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Risperidone and Methylphenidate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these medicines can increase the chance of developing movement problems, especially if the dose of either drug is changed.
FDA Label Information
Methylphenidate Concomitant use with methylphenidate, when there is change in dosage of either medication, may increase the risk of extrapyramidal symptoms (EPS). Monitor for symptoms of EPS with concomitant use of risperidone tablets and methylphenidate [see Adverse Reactions ( 6.2 )].
Risperidone Also Interacts With
- Amitriptyline major
- Carbamazepine major
- Lithium major
- Erythromycin major
- Ranitidine major
Methylphenidate Also Interacts With
- Safinamide major
- Dexmethylphenidate moderate
- Linezolid minor
- Phenelzine minor
- Tranylcypromine minor
Frequently Asked Questions
What SPL severity band is on file for Risperidone + Methylphenidate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Risperidone has 20 labeled pairs on file vs Methylphenidate's 11. In the moderate band specifically: Risperidone has 5 (also Valproate, Digoxin, Dexmethylphenidate, Tetrabenazine); Methylphenidate has 2 (also Dexmethylphenidate).
What mechanism field is on file for Risperidone and Methylphenidate?
Combining these medicines can increase the chance of developing movement problems, especially if the dose of either drug is changed.
Risperidone carries more major-labeled pairs than Methylphenidate
SPL source-record counts only. This page's band is moderate · classes on file: Risperidone (Atypical Antipsychotic); Methylphenidate (CNS Stimulant).
Risperidone has 6 major-labeled pairs vs Methylphenidate's 1. This page itself is in the moderate band, not the major band.
6 major · 5 moderate · 9 minor · 20 total
- Other moderate peers for Risperidone
- Valproate
- Digoxin
- Dexmethylphenidate
- Tetrabenazine
1 major · 2 moderate · 8 minor · 11 total
- Other moderate peers for Methylphenidate
- Dexmethylphenidate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.