Risperidone and Digoxin Interaction
Drug interaction information between Risperidone and Digoxin.
Risperidone and Digoxin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Risperidone and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Risperidone does not have a meaningful effect on how your body handles digoxin.
FDA Label Information
Digoxin Risperidone tablets (0.25 mg twice daily) did not show a clinically relevant effect on the pharmacokinetics of digoxin. Dose adjustment for digoxin is not recommended.
Risperidone Also Interacts With
- Amitriptyline major
- Carbamazepine major
- Lithium major
- Erythromycin major
- Ranitidine major
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Risperidone + Digoxin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Risperidone's 20. In the moderate band specifically: Risperidone has 5 (also Methylphenidate, Valproate, Dexmethylphenidate, Tetrabenazine); Digoxin has 13 (also Sotalol, Dofetilide, Ivabradine, Dopamine).
What mechanism field is on file for Risperidone and Digoxin?
Risperidone does not have a meaningful effect on how your body handles digoxin.
Risperidone carries more major-labeled pairs than Digoxin
SPL source-record counts only. This page's band is moderate · classes on file: Risperidone (Atypical Antipsychotic); Digoxin (Cardiac Glycoside).
Risperidone has 6 major-labeled pairs vs Digoxin's 2. This page itself is in the moderate band, not the major band.
6 major · 5 moderate · 9 minor · 20 total
- Other moderate peers for Risperidone
- Methylphenidate
- Valproate
- Dexmethylphenidate
- Tetrabenazine
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Sotalol
- Dofetilide
- Ivabradine
- Dopamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.