Risedronate and Aspirin Interaction
Drug interaction information between Risedronate and Aspirin.
Risedronate and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Risedronate and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can be tough on the stomach lining, and taking them together increases the chance of having stomach pain or irritation.
FDA Label Information
7.4 Aspirin/Nonsteroidal Anti-Inflammatory Drugs In the Phase 3 study comparing risedronate sodium 35 mg once-a-week immediately following breakfast and risedronate sodium 5 mg daily, 18% of NSAID users (any use) in both groups developed upper gastrointestinal adverse reactions.
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Risedronate + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Risedronate's 2. In the minor band specifically: Risedronate has 2 (also Esomeprazole); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Risedronate and Aspirin?
Both of these drugs can be tough on the stomach lining, and taking them together increases the chance of having stomach pain or irritation.
Aspirin carries more major-labeled pairs than Risedronate
SPL source-record counts only. This page's band is minor · classes on file: Risedronate (Bisphosphonate); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Risedronate's 0. This page itself is in the minor band, not the major band.
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.