What the FDA labels say about taking them together
Esomeprazole and risedronate
Risedronate's FDA label (Risedronate Sodium) of February 3, 2026 names esomeprazole in its drug interactions section; the esomeprazole labels PlainMeds reads (3) do not name risedronate. The risedronate label: “Co-administration of Risedronate sodium delayed-release with the PPI, esomeprazole, increased risedronate bioavailability.”
Check it at the source: the esomeprazole FDA label on DailyMed (effective March 19, 2024, Haleon US Holdings LLC); the risedronate FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals, Inc.).
What does the esomeprazole label say about risedronate?
Esomeprazole's label (effective March 19, 2024) and its 2 other brand-application labels do not name risedronate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nexium 24HR), NDA204655 (Astrazeneca Lp), as published by Haleon US Holdings LLC, effective March 19, 2024 (SPL set 4513934d-0cf0-40fc-a348-b4e75a33b094), via openFDA; the full label on DailyMed
What does the risedronate label say about esomeprazole?
Risedronate Sodium label (Mylan Pharmaceuticals, Inc., February 3, 2026), drug interactionsCo-administration of Risedronate sodium delayed-release with the PPI, esomeprazole, increased risedronate bioavailability.
Source: FDA drug label (Risedronate Sodium, NDA022560), Mylan Pharmaceuticals, Inc., effective February 3, 2026 (SPL set c89430be-15f1-4b8b-ab7e-738de716ee7d), via openFDA
Source: FDA drug label (Risedronate Sodium), NDA020835 (Apil), as published by Mylan Pharmaceuticals, Inc., effective February 12, 2026 (SPL set f715718a-407d-4e2a-9834-74a8f1361d03), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Esomeprazole | Risedronate | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Osteoporosis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.145 per capsule 20 mg capsule | $12.91 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once