Risedronate and Esomeprazole Interaction
Drug interaction information between Risedronate and Esomeprazole.
Risedronate and Esomeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Risedronate and Esomeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This acid-reducing medicine can cause your body to absorb a larger amount of the bone medication than it normally would.
FDA Label Information
Co-administration of risedronate sodium with the PPI, esomeprazole, increased risedronate bioavailability.
Esomeprazole Also Interacts With
- Posaconazole major
- Clopidogrel moderate
- Digoxin minor
Frequently Asked Questions
What SPL severity band is on file for Risedronate + Esomeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Esomeprazole has 4 labeled pairs on file vs Risedronate's 2. In the minor band specifically: Risedronate has 2 (also Aspirin); Esomeprazole has 2 (also Digoxin).
What mechanism field is on file for Risedronate and Esomeprazole?
This acid-reducing medicine can cause your body to absorb a larger amount of the bone medication than it normally would.
Esomeprazole carries more major-labeled pairs than Risedronate
SPL source-record counts only. This page's band is minor · classes on file: Risedronate (Bisphosphonate); Esomeprazole (Proton Pump Inhibitor (PPI)).
Esomeprazole has 1 major-labeled pair vs Risedronate's 0. This page itself is in the minor band, not the major band.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.