Apixaban and Heparin Interaction
Drug interaction information between Apixaban and Heparin.
Apixaban and Heparin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Apixaban and Heparin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs are blood thinners that prevent your blood from clotting. Using them together can make your blood too thin and increase your risk of serious bleeding.
FDA Label Information
7.3 Anticoagulants and Antiplatelet Agents Coadministration of antiplatelet agents, fibrinolytics, heparin, aspirin, and chronic NSAID use increases the risk of bleeding.
Apixaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Carbamazepine moderate
- Rifampin moderate
Heparin Also Interacts With
- Ibuprofen moderate
- Celecoxib moderate
- Hydroxychloroquine moderate
- Indomethacin moderate
- Dipyridamole moderate
Frequently Asked Questions
What SPL severity band is on file for Apixaban + Heparin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Heparin has 20 labeled pairs on file vs Apixaban's 12. In the moderate band specifically: Apixaban has 9 (also Clopidogrel, Aspirin, Warfarin, Carbamazepine); Heparin has 10 (also Ibuprofen, Celecoxib, Hydroxychloroquine, Indomethacin).
What mechanism field is on file for Apixaban and Heparin?
Both drugs are blood thinners that prevent your blood from clotting. Using them together can make your blood too thin and increase your risk of serious bleeding.
Heparin's labeled portfolio outnumbers Apixaban
SPL source-record counts only. This page's band is moderate · classes on file: Apixaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Heparin (Unfractionated Heparin).
0 major · 9 moderate · 3 minor · 12 total
- Other moderate peers for Apixaban
- Clopidogrel
- Aspirin
- Warfarin
- Carbamazepine
0 major · 10 moderate · 10 minor · 20 total
- Other moderate peers for Heparin
- Ibuprofen
- Celecoxib
- Hydroxychloroquine
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.