Ramipril and Amiloride Interaction
Drug interaction information between Ramipril and Amiloride.
Ramipril and Amiloride have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ramipril and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs cause your body to hold onto potassium instead of getting rid of it through your urine. This can lead to a dangerous buildup of potassium in your blood.
FDA Label Information
Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia.
Ramipril Also Interacts With
- Spironolactone moderate
- Telmisartan moderate
- Lithium moderate
- Simvastatin minor
- Furosemide minor
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Ramipril + Amiloride?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Ramipril's 11. In the moderate band specifically: Ramipril has 4 (also Spironolactone, Telmisartan, Lithium); Amiloride has 7 (also Cyclosporine, Lithium, Amlodipine/Benazepril, Benazepril).
What mechanism field is on file for Ramipril and Amiloride?
Both of these drugs cause your body to hold onto potassium instead of getting rid of it through your urine. This can lead to a dangerous buildup of potassium in your blood.
Amiloride carries more major-labeled pairs than Ramipril
SPL source-record counts only. This page's band is moderate · classes on file: Ramipril (ACE Inhibitor); Amiloride (Potassium-Sparing Diuretic).
Amiloride has 1 major-labeled pair vs Ramipril's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Ramipril
- Spironolactone
- Telmisartan
- Lithium
1 major · 7 moderate · 11 minor · 19 total
- Other moderate peers for Amiloride
- Cyclosporine
- Lithium
- Amlodipine/Benazepril
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.