Ramipril and Lithium Interaction
Drug interaction information between Ramipril and Lithium.
Ramipril and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ramipril and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ramipril can make it harder for your kidneys to remove lithium from your body, which can cause lithium to reach toxic levels.
FDA Label Information
• Lithium: Use with caution ( 7.3 ). 7.3 Lithium Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving ACE inhibitors during therapy with lithium; therefore, frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, the risk of lithium toxicity may be increased.
Ramipril Also Interacts With
- Spironolactone moderate
- Telmisartan moderate
- Amiloride moderate
- Simvastatin minor
- Furosemide minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Ramipril + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Ramipril's 11. In the moderate band specifically: Ramipril has 4 (also Spironolactone, Telmisartan, Amiloride); Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Ramipril and Lithium?
Ramipril can make it harder for your kidneys to remove lithium from your body, which can cause lithium to reach toxic levels.
Lithium carries more major-labeled pairs than Ramipril
SPL source-record counts only. This page's band is moderate · classes on file: Ramipril (ACE Inhibitor); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Ramipril's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Ramipril
- Spironolactone
- Telmisartan
- Amiloride
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.