Ramipril and Spironolactone Interaction
Drug interaction information between Ramipril and Spironolactone.
Ramipril and Spironolactone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ramipril and Spironolactone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can cause your body to hold onto potassium, which may lead to dangerously high potassium levels in your blood.
FDA Label Information
Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) or potassium supplements can increase the risk of hyperkalemia.
Ramipril Also Interacts With
- Telmisartan moderate
- Lithium moderate
- Amiloride moderate
- Simvastatin minor
- Furosemide minor
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Ramipril + Spironolactone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Spironolactone has 23 labeled pairs on file vs Ramipril's 11. In the moderate band specifically: Ramipril has 4 (also Telmisartan, Lithium, Amiloride); Spironolactone has 9 (also Lithium, Trimethoprim, Heparin, Amlodipine/Benazepril).
What mechanism field is on file for Ramipril and Spironolactone?
Both of these medicines can cause your body to hold onto potassium, which may lead to dangerously high potassium levels in your blood.
Spironolactone's labeled portfolio outnumbers Ramipril
SPL source-record counts only. This page's band is moderate · classes on file: Ramipril (ACE Inhibitor); Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist).
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Ramipril
- Telmisartan
- Lithium
- Amiloride
0 major · 9 moderate · 14 minor · 23 total
- Other moderate peers for Spironolactone
- Lithium
- Trimethoprim
- Heparin
- Amlodipine/Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.