Ramipril and Simvastatin Interaction
Drug interaction information between Ramipril and Simvastatin.
Ramipril and Simvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ramipril and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medicines do not have any known effect on how the other one works or is processed.
FDA Label Information
7.6 Other Neither ramipril nor its metabolites have been found to interact with food, digoxin, antacid, furosemide, cimetidine, indomethacin, and simvastatin.
Ramipril Also Interacts With
- Spironolactone moderate
- Telmisartan moderate
- Lithium moderate
- Amiloride moderate
- Furosemide minor
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Ramipril + Simvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Ramipril's 11. In the minor band specifically: Ramipril has 7 (also Furosemide, Propranolol, Warfarin, Digoxin); Simvastatin has 21 (also Fenofibrate, Ketoconazole, Erythromycin, Clarithromycin).
What mechanism field is on file for Ramipril and Simvastatin?
These two medicines do not have any known effect on how the other one works or is processed.
Simvastatin carries more major-labeled pairs than Ramipril
SPL source-record counts only. This page's band is minor · classes on file: Ramipril (ACE Inhibitor); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Ramipril's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Ramipril
- Furosemide
- Propranolol
- Warfarin
- Digoxin
11 major · 9 moderate · 21 minor · 41 total
- Other minor peers for Simvastatin
- Fenofibrate
- Ketoconazole
- Erythromycin
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.