Ramipril and Telmisartan Interaction
Drug interaction information between Ramipril and Telmisartan.
Ramipril and Telmisartan have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ramipril and Telmisartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two types of blood pressure medicines together can put too much stress on your kidneys and increase the risk of kidney damage.
FDA Label Information
In a large-scale, long-term clinical efficacy study, the combination of telmisartan and ramipril resulted in an increased incidence of clinically important renal dysfunction (death, doubling of serum creatinine, dialysis) compared with groups receiving either drug alone. Therefore, concomitant use of telmisartan and ramipril is not recommended [see Dual Blockade of the Renin-Angiotensin-Aldosterone System ( 5.7 ) ].
Ramipril Also Interacts With
- Spironolactone moderate
- Lithium moderate
- Amiloride moderate
- Simvastatin minor
- Furosemide minor
Telmisartan Also Interacts With
View all Telmisartan interactions →Frequently Asked Questions
What SPL severity band is on file for Ramipril + Telmisartan?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ramipril has 11 labeled pairs on file vs Telmisartan's 4. In the moderate band specifically: Ramipril has 4 (also Spironolactone, Lithium, Amiloride); Telmisartan has 1.
What mechanism field is on file for Ramipril and Telmisartan?
Taking these two types of blood pressure medicines together can put too much stress on your kidneys and increase the risk of kidney damage.
Telmisartan carries more major-labeled pairs than Ramipril
SPL source-record counts only. This page's band is moderate · classes on file: Ramipril (ACE Inhibitor); Telmisartan (Angiotensin II Receptor Blocker (ARB)).
Telmisartan has 1 major-labeled pair vs Ramipril's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other moderate peers for Ramipril
- Spironolactone
- Lithium
- Amiloride
1 major · 1 moderate · 2 minor · 4 total
Telmisartan has no other moderate-band peer in this dataset besides Ramipril.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.