Rabeprazole and Clarithromycin Interaction
Drug interaction information between Rabeprazole and Clarithromycin.
Rabeprazole and Clarithromycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rabeprazole and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can change how they are processed, potentially leading to serious and life-threatening heart rhythm issues.
FDA Label Information
Combination Therapy with Clarithromycin and Amoxicillin Clinical Impact: Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and are contraindicated. Intervention: See Contraindications and Warnings and Precautions in prescribing information for clarithromycin.
Rabeprazole Also Interacts With
- Amoxicillin major
- Warfarin minor
- Methotrexate minor
- Ketoconazole minor
- Itraconazole minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Rabeprazole + Clarithromycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Rabeprazole's 7. In the major band specifically: Rabeprazole has 2 (also Amoxicillin); Clarithromycin has 16 (also Quetiapine, Pioglitazone, Fluconazole, Cyclosporine).
What mechanism field is on file for Rabeprazole and Clarithromycin?
Taking these drugs together can change how they are processed, potentially leading to serious and life-threatening heart rhythm issues.
Clarithromycin carries more major-labeled pairs than Rabeprazole
SPL source-record counts only. This page's band is major · classes on file: Rabeprazole (Proton Pump Inhibitor (PPI)); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Rabeprazole's 2.
16 major · 35 moderate · 30 minor · 81 total
- Other major peers for Clarithromycin
- Quetiapine
- Pioglitazone
- Fluconazole
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.