Rabeprazole and Methotrexate Interaction
Drug interaction information between Rabeprazole and Methotrexate.
Rabeprazole and Methotrexate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rabeprazole and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rabeprazole can keep methotrexate in your body longer than usual, which might lead to dangerous levels of the drug in your blood.
FDA Label Information
Methotrexate Clinical Impact: Concomitant use of rabeprazole with methotrexate (primarily at high dose) may elevate and prolong serum levels of methotrexate and/or its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. No formal drug interaction studies of methotrexate with PPIs have been conducted [see Warnings and Precautions ( 5.9 )]. Intervention: A temporary withdrawal of rabeprazole sodium delayed-release tablets may be considered in some patients receiving high dose methotrexate administration.
Rabeprazole Also Interacts With
- Amoxicillin major
- Clarithromycin major
- Warfarin minor
- Ketoconazole minor
- Itraconazole minor
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Rabeprazole + Methotrexate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Rabeprazole's 7. In the minor band specifically: Rabeprazole has 5 (also Warfarin, Ketoconazole, Itraconazole, Digoxin); Methotrexate has 26 (also Aspirin, Folic Acid, Probenecid, Phenytoin).
What mechanism field is on file for Rabeprazole and Methotrexate?
Rabeprazole can keep methotrexate in your body longer than usual, which might lead to dangerous levels of the drug in your blood.
Rabeprazole carries more major-labeled pairs than Methotrexate
SPL source-record counts only. This page's band is minor · classes on file: Rabeprazole (Proton Pump Inhibitor (PPI)); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
Rabeprazole has 2 major-labeled pairs vs Methotrexate's 0. This page itself is in the minor band, not the major band.
2 major · 0 moderate · 5 minor · 7 total
- Other minor peers for Rabeprazole
- Warfarin
- Ketoconazole
- Itraconazole
- Digoxin
0 major · 12 moderate · 26 minor · 38 total
- Other minor peers for Methotrexate
- Aspirin
- Folic Acid
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.