Rabeprazole and Warfarin Interaction
Drug interaction information between Rabeprazole and Warfarin.
Rabeprazole and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rabeprazole and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rabeprazole can cause warfarin to stay in your system longer, which increases the risk of bleeding.
FDA Label Information
Warfarin Clinical Impact: Increased INR and prothrombin time in patients receiving PPIs, including rabeprazole, and warfarin concomitantly. Dose adjustment of warfarin may be needed to maintain target INR range. See prescribing information for warfarin.
Rabeprazole Also Interacts With
- Amoxicillin major
- Clarithromycin major
- Methotrexate minor
- Ketoconazole minor
- Itraconazole minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Rabeprazole + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Rabeprazole's 7. In the minor band specifically: Rabeprazole has 5 (also Methotrexate, Ketoconazole, Itraconazole, Digoxin); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Rabeprazole and Warfarin?
Rabeprazole can cause warfarin to stay in your system longer, which increases the risk of bleeding.
Warfarin's labeled portfolio outnumbers Rabeprazole
SPL source-record counts only. This page's band is minor · classes on file: Rabeprazole (Proton Pump Inhibitor (PPI)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
2 major · 0 moderate · 5 minor · 7 total
- Other minor peers for Rabeprazole
- Methotrexate
- Ketoconazole
- Itraconazole
- Digoxin
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.