What the FDA labels say about taking them together
Rabeprazole and warfarin
Rabeprazole's FDA label of January 27, 2026 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name rabeprazole. The rabeprazole label: “Increased INR and prothrombin time in patients receiving PPIs, including rabeprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death.”
Check it at the source: the rabeprazole FDA label on DailyMed (effective January 27, 2026, Waylis Therapeutics LLC); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the rabeprazole label say about warfarin?
Rabeprazole label, drug interactionsClinical Impact: Increased INR and prothrombin time in patients receiving PPIs, including rabeprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Intervention: Monitor INR and prothrombin time. Dose adjustment of warfarin may be needed to maintain target INR range. See prescribing information for warfarin.
Rabeprazole label, warnings and precautionsUse with Warfarin: Monitor for increases in INR and prothrombin time ( 5.2 , 7 ).
Source: FDA drug label (Aciphex), Waylis Therapeutics LLC, effective January 27, 2026 (SPL set 1eb38279-0237-4967-be7a-c53a826c1138), via openFDA; the full label on DailyMed
What does the warfarin label say about rabeprazole?
Warfarin's label (effective May 29, 2026) does not name rabeprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rabeprazole | Warfarin | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.224 per tablet 20 mg tablet | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once