Rabeprazole and Warfarin Interaction
Drug interaction information between Rabeprazole and Warfarin.
Rabeprazole and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rabeprazole and Warfarin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Rabeprazole can cause warfarin to stay in your system longer, which increases the risk of bleeding.
What To Do
Your doctor should monitor your blood clotting levels closely and may need to adjust your warfarin dose.
FDA Label Information
Warfarin Clinical Impact: Increased INR and prothrombin time in patients receiving PPIs, including rabeprazole, and warfarin concomitantly. Dose adjustment of warfarin may be needed to maintain target INR range. See prescribing information for warfarin.
Rabeprazole Also Interacts With
- Amoxicillin major
- Clarithromycin major
- Methotrexate minor
- Ketoconazole minor
- Itraconazole minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
Can I take Rabeprazole and Warfarin together?
This is a minor interaction. Your doctor should monitor your blood clotting levels closely and may need to adjust your warfarin dose.
How serious is the interaction between Rabeprazole and Warfarin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Rabeprazole and Warfarin interact?
Rabeprazole can cause warfarin to stay in your system longer, which increases the risk of bleeding.
Understanding the Rabeprazole and Warfarin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Rabeprazole belongs to the Proton Pump Inhibitor (PPI) class and Warfarin belongs to the Vitamin K Antagonist (Anticoagulant) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Rabeprazole can cause warfarin to stay in your system longer, which increases the risk of bleeding. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Rabeprazole has 7 total documented interactions on file in this dataset, and Warfarin has 163. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your blood clotting levels closely and may need to adjust your warfarin dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Rabeprazole or Warfarin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.