Rabeprazole and Itraconazole Interaction
Drug interaction information between Rabeprazole and Itraconazole.
Rabeprazole and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rabeprazole and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rabeprazole lowers stomach acid, which makes it harder for your body to absorb itraconazole correctly.
FDA Label Information
Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole, itraconazole) Clinical Impact: Rabeprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.
Rabeprazole Also Interacts With
- Amoxicillin major
- Clarithromycin major
- Warfarin minor
- Methotrexate minor
- Ketoconazole minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Rabeprazole + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Rabeprazole's 7. In the minor band specifically: Rabeprazole has 5 (also Warfarin, Methotrexate, Ketoconazole, Digoxin); Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Rabeprazole and Itraconazole?
Rabeprazole lowers stomach acid, which makes it harder for your body to absorb itraconazole correctly.
Itraconazole carries more major-labeled pairs than Rabeprazole
SPL source-record counts only. This page's band is minor · classes on file: Rabeprazole (Proton Pump Inhibitor (PPI)); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Rabeprazole's 2. This page itself is in the minor band, not the major band.
2 major · 0 moderate · 5 minor · 7 total
- Other minor peers for Rabeprazole
- Warfarin
- Methotrexate
- Ketoconazole
- Digoxin
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.