Rabeprazole and Amoxicillin Interaction
Drug interaction information between Rabeprazole and Amoxicillin.
Rabeprazole and Amoxicillin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Rabeprazole and Amoxicillin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rabeprazole changes the acid levels in your stomach, which can affect how the antibiotic amoxicillin is absorbed and used by your body.
FDA Label Information
Combination Therapy with Clarithromycin and Amoxicillin Clinical Impact: Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and are contraindicated. Amoxicillin also has drug interactions. See Drug Interactions in prescribing information for amoxicillin.
Rabeprazole Also Interacts With
- Clarithromycin major
- Warfarin minor
- Methotrexate minor
- Ketoconazole minor
- Itraconazole minor
Amoxicillin Also Interacts With
- Lansoprazole major
- Theophylline major
- Allopurinol moderate
- Probenecid moderate
- Estradiol minor
Frequently Asked Questions
What SPL severity band is on file for Rabeprazole + Amoxicillin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amoxicillin has 12 labeled pairs on file vs Rabeprazole's 7. In the major band specifically: Rabeprazole has 2 (also Clarithromycin); Amoxicillin has 3 (also Lansoprazole, Theophylline).
What mechanism field is on file for Rabeprazole and Amoxicillin?
Rabeprazole changes the acid levels in your stomach, which can affect how the antibiotic amoxicillin is absorbed and used by your body.
Amoxicillin carries more major-labeled pairs than Rabeprazole
SPL source-record counts only. This page's band is major · classes on file: Rabeprazole (Proton Pump Inhibitor (PPI)); Amoxicillin (Penicillin Antibiotic).
Amoxicillin has 3 major-labeled pairs vs Rabeprazole's 2.
2 major · 0 moderate · 5 minor · 7 total
- Other major peers for Rabeprazole
- Clarithromycin
3 major · 2 moderate · 7 minor · 12 total
- Other major peers for Amoxicillin
- Lansoprazole
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.