Propranolol and Haloperidol Interaction
Drug interaction information between Propranolol and Haloperidol.
Propranolol and Haloperidol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Propranolol and Haloperidol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs can lower blood pressure and affect the heart's rhythm, which can lead to a dangerous drop in blood pressure or heart failure.
What To Do
Your doctor should monitor your heart rate and blood pressure very closely if you take these together.
FDA Label Information
Neuroleptic Drugs Hypotension and cardiac arrest have been reported with the concomitant use of propranolol and haloperidol.
Propranolol Also Interacts With
View all Propranolol interactions →Haloperidol Also Interacts With
- Fluoxetine moderate
- Tetrabenazine moderate
- Bromocriptine minor
- Bupropion minor
- Carbamazepine minor
Frequently Asked Questions
Can I take Propranolol and Haloperidol together?
This is a minor interaction. Your doctor should monitor your heart rate and blood pressure very closely if you take these together.
How serious is the interaction between Propranolol and Haloperidol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Propranolol and Haloperidol interact?
Both drugs can lower blood pressure and affect the heart's rhythm, which can lead to a dangerous drop in blood pressure or heart failure.
Understanding the Propranolol and Haloperidol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Propranolol belongs to the Non-Selective Beta-Blocker class and Haloperidol belongs to the Typical Antipsychotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs can lower blood pressure and affect the heart's rhythm, which can lead to a dangerous drop in blood pressure or heart failure. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Propranolol has 44 total documented interactions on file in this dataset, and Haloperidol has 14. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your heart rate and blood pressure very closely if you take these together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Propranolol or Haloperidol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.