Propranolol and Haloperidol Interaction
Drug interaction information between Propranolol and Haloperidol.
Propranolol and Haloperidol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Propranolol and Haloperidol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can lower blood pressure and affect the heart's rhythm, which can lead to a dangerous drop in blood pressure or heart failure.
FDA Label Information
Neuroleptic Drugs Hypotension and cardiac arrest have been reported with the concomitant use of propranolol and haloperidol.
Propranolol Also Interacts With
View all Propranolol interactions →Haloperidol Also Interacts With
- Fluoxetine moderate
- Tetrabenazine moderate
- Bromocriptine minor
- Bupropion minor
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Propranolol + Haloperidol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Haloperidol's 14. In the minor band specifically: Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil); Haloperidol has 12 (also Bromocriptine, Bupropion, Carbamazepine, Clomipramine).
What mechanism field is on file for Propranolol and Haloperidol?
Both drugs can lower blood pressure and affect the heart's rhythm, which can lead to a dangerous drop in blood pressure or heart failure.
Propranolol's labeled portfolio outnumbers Haloperidol
SPL source-record counts only. This page's band is minor · classes on file: Propranolol (Non-Selective Beta-Blocker); Haloperidol (Typical Antipsychotic).
0 major · 0 moderate · 44 minor · 44 total
0 major · 2 moderate · 12 minor · 14 total
- Other minor peers for Haloperidol
- Bromocriptine
- Bupropion
- Carbamazepine
- Clomipramine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.