Lamotrigine and Desmopressin Interaction
Drug interaction information between Lamotrigine and Desmopressin.
Lamotrigine and Desmopressin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lamotrigine and Desmopressin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking lamotrigine with desmopressin can increase the risk of your body holding onto too much water and lowering your salt levels.
What To Do
Your doctor should carefully monitor your blood work and symptoms while you are on both medications.
FDA Label Information
tricyclic antidepressants, selective serotonin re-uptake inhibitors, chlorpromazine, opiate analgesics, NSAIDs, lamotrigine and carbamazepine) should be performed with caution.
Lamotrigine Also Interacts With
- Dofetilide moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
- Phenytoin minor
Desmopressin Also Interacts With
- Carbamazepine moderate
- Chlorpromazine moderate
Frequently Asked Questions
Can I take Lamotrigine and Desmopressin together?
This is a moderate interaction. Your doctor should carefully monitor your blood work and symptoms while you are on both medications.
How serious is the interaction between Lamotrigine and Desmopressin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Lamotrigine and Desmopressin interact?
Taking lamotrigine with desmopressin can increase the risk of your body holding onto too much water and lowering your salt levels.
Understanding the Lamotrigine and Desmopressin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Lamotrigine belongs to the Anticonvulsant class and Desmopressin belongs to the Vasopressin Analog class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking lamotrigine with desmopressin can increase the risk of your body holding onto too much water and lowering your salt levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Lamotrigine has 24 total documented interactions on file in this dataset, and Desmopressin has 3. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should carefully monitor your blood work and symptoms while you are on both medications. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Lamotrigine or Desmopressin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.