Lamotrigine and Dofetilide Interaction
Drug interaction information between Lamotrigine and Dofetilide.
Lamotrigine and Dofetilide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lamotrigine and Dofetilide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lamotrigine can change how the body handles dofetilide, a drug that can be dangerous if levels are slightly off.
FDA Label Information
Coadministration of lamotrigine with OCT2 substrates with a narrow therapeutic index (e.g., dofetilide) is not recommended.
Lamotrigine Also Interacts With
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
- Phenytoin minor
Dofetilide Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir major
- Dolutegravir major
- Dolutegravir/Lamivudine major
- Itraconazole major
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Lamotrigine + Dofetilide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lamotrigine has 24 labeled pairs on file vs Dofetilide's 8. In the moderate band specifically: Lamotrigine has 2 (also Desmopressin); Dofetilide has 3 (also Clarithromycin, Digoxin).
What mechanism field is on file for Lamotrigine and Dofetilide?
Lamotrigine can change how the body handles dofetilide, a drug that can be dangerous if levels are slightly off.
Dofetilide carries more major-labeled pairs than Lamotrigine
SPL source-record counts only. This page's band is moderate · classes on file: Lamotrigine (Anticonvulsant); Dofetilide (Class III Antiarrhythmic).
Dofetilide has 4 major-labeled pairs vs Lamotrigine's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 22 minor · 24 total
- Other moderate peers for Lamotrigine
- Desmopressin
4 major · 3 moderate · 1 minor · 8 total
- Other moderate peers for Dofetilide
- Clarithromycin
- Digoxin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.