What the FDA labels say about taking them together
Dofetilide and lamotrigine
Lamotrigine's FDA label of October 10, 2025 names dofetilide in its drug interactions section; the dofetilide label PlainMeds reads does not name lamotrigine.
Check it at the source: the dofetilide FDA label on DailyMed (effective April 21, 2026, Pfizer Laboratories Div Pfizer Inc); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the dofetilide label say about lamotrigine?
Dofetilide's label (effective April 21, 2026) does not name lamotrigine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tikosyn), Pfizer Laboratories Div Pfizer Inc, effective April 21, 2026 (SPL set 02438044-d6a3-49e9-a1ac-3aad21ef2c8c), via openFDA; the full label on DailyMed
What does the lamotrigine label say about dofetilide?
Lamotrigine label, drug interactionsNamed in a table that the FDA label file prints without its column breaks; the full label shows the table.
Source: FDA drug label (Lamictal Xr, NDA022115), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set 3e2c9a35-6a39-41d7-ad84-3c0bb8894b09), via openFDA
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dofetilide | Lamotrigine | |
|---|---|---|
| Labeled for | Atrial fibrillation | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.203 per capsule 125 mcg capsule | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once