Tamsulosin and Dutasteride Interaction
Drug interaction information between Tamsulosin and Dutasteride.
Tamsulosin and Dutasteride have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tamsulosin and Dutasteride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs are processed by the same system in your liver, which could change the amount of medicine that stays in your blood.
FDA Label Information
7 DRUG INTERACTIONS There have been no drug interaction trials using dutasteride and tamsulosin hydrochloride capsules. Because of the potential for drug-drug interactions, use caution when prescribing a dutasteride-containing product, including dutasteride and tamsulosin hydrochloride capsules, to patients taking potent, chronic CYP3A4 enzyme inhibitors (e.g., ritonavir) [see Clinical Pharmacology ( 12.3 ) ] . Tamsulosin Strong and Moderate Inhibitors of CYP3A4 or CYP2D6: Tamsulosin is extensively metabolized, mainly by CYP3A4 or CYP2D6.
Tamsulosin Also Interacts With
- Furosemide major
- Paroxetine moderate
- Warfarin moderate
- Erythromycin moderate
- Terbinafine moderate
Dutasteride Also Interacts With
- Furosemide major
- Warfarin moderate
- Paroxetine minor
- Atenolol minor
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Tamsulosin + Dutasteride?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tamsulosin has 18 labeled pairs on file vs Dutasteride's 16. In the moderate band specifically: Tamsulosin has 8 (also Paroxetine, Warfarin, Erythromycin, Terbinafine); Dutasteride has 2 (also Warfarin).
What mechanism field is on file for Tamsulosin and Dutasteride?
These drugs are processed by the same system in your liver, which could change the amount of medicine that stays in your blood.
Tamsulosin's labeled portfolio outnumbers Dutasteride
SPL source-record counts only. This page's band is moderate · classes on file: Tamsulosin (Alpha-1 Adrenergic Blocker); Dutasteride (5-Alpha Reductase Inhibitor).
1 major · 8 moderate · 9 minor · 18 total
- Other moderate peers for Tamsulosin
- Paroxetine
- Warfarin
- Erythromycin
- Terbinafine
1 major · 2 moderate · 13 minor · 16 total
- Other moderate peers for Dutasteride
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.