Nirmatrelvir/Ritonavir and Amiodarone Interaction
Drug interaction information between Nirmatrelvir/Ritonavir and Amiodarone.
Nirmatrelvir/Ritonavir and Amiodarone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Nirmatrelvir/Ritonavir and Amiodarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ritonavir slows down how the body breaks down amiodarone, causing the heart medicine to build up to dangerous levels. This increase can lead to serious and life-threatening heart rhythm problems.
FDA Label Information
Antiarrhythmics amiodarone, dronedarone, flecainide, propafenone, quinidine ↑ antiarrhythmic Co-administration contraindicated due to potential for cardiac arrhythmias [see Contraindications (4) ] .
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Amiodarone Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Lithium moderate
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Nirmatrelvir/Ritonavir + Amiodarone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Amiodarone's 42. In the major band specifically: Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Lovastatin, Sildenafil, Carbamazepine); Amiodarone has 4 (also Ezetimibe, Ezetimibe/Simvastatin, Simvastatin).
What mechanism field is on file for Nirmatrelvir/Ritonavir and Amiodarone?
Ritonavir slows down how the body breaks down amiodarone, causing the heart medicine to build up to dangerous levels. This increase can lead to serious and life-threatening heart rhythm problems.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Amiodarone
SPL source-record counts only. This page's band is major · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Amiodarone (Class III Antiarrhythmic).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Amiodarone's 4.
23 major · 30 moderate · 33 minor · 86 total
- Other major peers for Nirmatrelvir/Ritonavir
- Simvastatin
- Lovastatin
- Sildenafil
- Carbamazepine
4 major · 9 moderate · 29 minor · 42 total
- Other major peers for Amiodarone
- Ezetimibe
- Ezetimibe/Simvastatin
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.