Naltrexone and Nabilone Interaction
Drug interaction information between Naltrexone and Nabilone.
Naltrexone and Nabilone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Naltrexone and Nabilone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs can have a combined effect that slows down your central nervous system, leading to increased sleepiness.
What To Do
Use caution when taking these together and report any excessive drowsiness to your healthcare provider.
FDA Label Information
CONCOMITANT DRUG CLINICAL EFFECT(S) Amphetamines, cocaine, other sympathomimetic agents Additive hypertension, tachycardia, possibly cardiotoxicity Atropine, scopolamine, antihistamines, other anticholinergic agents Additive or super-additive tachycardia, drowsiness Amitriptyline, amoxapine, desipramine, other tricyclic antidepressants Additive tachycardia, hypertension, drowsiness Barbiturates, benzodiazepines, ethanol, lithium, opioids, buspirone, antihistamines, muscle relaxants, other CNS depressants Additive drowsiness and CNS depression Disulfiram A reversible hypomanic reaction was...
Naltrexone Also Interacts With
- Thioridazine minor
- Disulfiram minor
- Acamprosate minor
- Glecaprevir/Pibrentasvir minor
Nabilone Also Interacts With
- Fluoxetine minor
- Buspirone minor
- Amitriptyline minor
- Diazepam minor
- Lithium minor
Frequently Asked Questions
Can I take Naltrexone and Nabilone together?
This is a minor interaction. Use caution when taking these together and report any excessive drowsiness to your healthcare provider.
How serious is the interaction between Naltrexone and Nabilone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Naltrexone and Nabilone interact?
These drugs can have a combined effect that slows down your central nervous system, leading to increased sleepiness.
Understanding the Naltrexone and Nabilone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Naltrexone belongs to the Opioid Antagonist class and Nabilone belongs to the Cannabinoid Antiemetic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs can have a combined effect that slows down your central nervous system, leading to increased sleepiness. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Naltrexone has 5 total documented interactions on file in this dataset, and Nabilone has 11. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use caution when taking these together and report any excessive drowsiness to your healthcare provider. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Naltrexone or Nabilone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.