Naltrexone and Nabilone Interaction
Drug interaction information between Naltrexone and Nabilone.
Naltrexone and Nabilone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Naltrexone and Nabilone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs can have a combined effect that slows down your central nervous system, leading to increased sleepiness.
FDA Label Information
CONCOMITANT DRUG CLINICAL EFFECT(S) Amphetamines, cocaine, other sympathomimetic agents Additive hypertension, tachycardia, possibly cardiotoxicity Atropine, scopolamine, antihistamines, other anticholinergic agents Additive or super-additive tachycardia, drowsiness Amitriptyline, amoxapine, desipramine, other tricyclic antidepressants Additive tachycardia, hypertension, drowsiness Barbiturates, benzodiazepines, ethanol, lithium, opioids, buspirone, antihistamines, muscle relaxants, other CNS depressants Additive drowsiness and CNS depression Disulfiram A reversible hypomanic reaction was...
Naltrexone Also Interacts With
- Thioridazine minor
- Disulfiram minor
- Acamprosate minor
- Glecaprevir/Pibrentasvir minor
Nabilone Also Interacts With
- Fluoxetine minor
- Buspirone minor
- Amitriptyline minor
- Diazepam minor
- Lithium minor
Frequently Asked Questions
What SPL severity band is on file for Naltrexone + Nabilone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nabilone has 11 labeled pairs on file vs Naltrexone's 5. In the minor band specifically: Naltrexone has 5 (also Thioridazine, Disulfiram, Acamprosate, Glecaprevir/Pibrentasvir); Nabilone has 11 (also Fluoxetine, Buspirone, Amitriptyline, Diazepam).
What mechanism field is on file for Naltrexone and Nabilone?
These drugs can have a combined effect that slows down your central nervous system, leading to increased sleepiness.
Nabilone's labeled portfolio outnumbers Naltrexone
SPL source-record counts only. This page's band is minor · classes on file: Naltrexone (Opioid Antagonist); Nabilone (Cannabinoid Antiemetic).
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Naltrexone
- Thioridazine
- Disulfiram
- Acamprosate
- Glecaprevir/Pibrentasvir
0 major · 0 moderate · 11 minor · 11 total
- Other minor peers for Nabilone
- Fluoxetine
- Buspirone
- Amitriptyline
- Diazepam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.