Naltrexone and Acamprosate Interaction
Drug interaction information between Naltrexone and Acamprosate.
Naltrexone and Acamprosate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Naltrexone and Acamprosate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not significantly change how the other works in your body.
FDA Label Information
The pharmacokinetics of acamprosate are not affected by alcohol, diazepam, or disulfiram, and clinically important interactions between naltrexone and acamprosate were not observed [ see Clinical Pharmacology (12.3) ].
Naltrexone Also Interacts With
- Thioridazine minor
- Disulfiram minor
- Glecaprevir/Pibrentasvir minor
- Nabilone minor
Frequently Asked Questions
What SPL severity band is on file for Naltrexone + Acamprosate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Naltrexone has 5 labeled pairs on file vs Acamprosate's 3. In the minor band specifically: Naltrexone has 5 (also Thioridazine, Disulfiram, Glecaprevir/Pibrentasvir, Nabilone); Acamprosate has 3 (also Diazepam, Disulfiram).
What mechanism field is on file for Naltrexone and Acamprosate?
These two drugs do not significantly change how the other works in your body.
Naltrexone's labeled portfolio outnumbers Acamprosate
SPL source-record counts only. This page's band is minor · classes on file: Naltrexone (Opioid Antagonist); Acamprosate (GABA Analog (Alcohol Dependence)).
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Naltrexone
- Thioridazine
- Disulfiram
- Glecaprevir/Pibrentasvir
- Nabilone
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Acamprosate
- Diazepam
- Disulfiram
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.