Naltrexone and Glecaprevir/Pibrentasvir Interaction
Drug interaction information between Naltrexone and Glecaprevir/Pibrentasvir.
Naltrexone and Glecaprevir/Pibrentasvir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Naltrexone and Glecaprevir/Pibrentasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is not enough research yet to know exactly how these two drugs affect each other in the body.
FDA Label Information
There is insufficient information to make a recommendation regarding the concomitant use of naltrexone with MAVYRET.
Naltrexone Also Interacts With
- Thioridazine minor
- Disulfiram minor
- Acamprosate minor
- Nabilone minor
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Frequently Asked Questions
What SPL severity band is on file for Naltrexone + Glecaprevir/Pibrentasvir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Naltrexone's 5. In the minor band specifically: Naltrexone has 5 (also Thioridazine, Disulfiram, Acamprosate, Nabilone); Glecaprevir/Pibrentasvir has 26 (also Atorvastatin, Amlodipine, Losartan, Omeprazole).
What mechanism field is on file for Naltrexone and Glecaprevir/Pibrentasvir?
There is not enough research yet to know exactly how these two drugs affect each other in the body.
Glecaprevir/Pibrentasvir carries more major-labeled pairs than Naltrexone
SPL source-record counts only. This page's band is minor · classes on file: Naltrexone (Opioid Antagonist); Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)).
Glecaprevir/Pibrentasvir has 3 major-labeled pairs vs Naltrexone's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Naltrexone
- Thioridazine
- Disulfiram
- Acamprosate
- Nabilone
3 major · 9 moderate · 26 minor · 38 total
- Other minor peers for Glecaprevir/Pibrentasvir
- Atorvastatin
- Amlodipine
- Losartan
- Omeprazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.