nabilone vs naltrexone
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Side-by-side comparison of nabilone and naltrexone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
CONCOMITANT DRUG CLINICAL EFFECT(S) Amphetamines, cocaine, other sympathomimetic agents Additive hypertension, tachycardia, possibly cardiotoxicity Atropine, scopolamine, antihistamines, other anticholinergic agents Additive or super-additive tachycardia, drowsiness Amitriptyline, amoxapine, desipramine, other tricyclic antidepressants Additive tachycardia, hypertension, drowsiness Barbiturates, benzodiazepines, ethanol, lithium, opioids, buspirone, antihistamines, muscle relaxants, other CNS depressants Additive drowsiness and CNS depression Disulfiram A reversible hypomanic reaction was...
Cesamet
Vivitrol, ReVia
Cesamet contains nabilone, a synthetic cannabinoid. It helps reduce nausea and vomiting caused by cancer chemotherapy when other medicines don't work.
Naltrexone is a medicine that can help treat alcohol and opioid dependence. It works by blocking the effects of opioids in your body.
Cesamet is used to treat nausea and vomiting caused by cancer chemotherapy. You should only use it if other anti-nausea medicines have not worked for you. This medicine can change your mental state, so someone should watch over you when you first start taking it and when your dose changes.
Naltrexone is used to treat alcohol dependence and to block the effects of opioid drugs. It is important to use naltrexone as part of a complete treatment plan. This plan should include counseling and support to help you stay sober or opioid-free.
Cesamet is a synthetic cannabinoid, similar to the active ingredient in marijuana. It works by affecting the parts of your brain that control nausea and vomiting. This helps to reduce these side effects of chemotherapy.
Naltrexone blocks the effects of opioids by attaching to opioid receptors in the brain. This prevents opioids from having their usual effects, like pain relief or feelings of euphoria. By blocking these effects, naltrexone can help reduce cravings for alcohol or opioids.
- • Drowsiness
- • Vertigo (feeling dizzy)
- • Dry mouth
- • Euphoria (feeling "high")
- • Ataxia (loss of coordination)
- • Nausea
- • Headache
- • Fatigue
- • Insomnia
- • Anxiety
- Pain 473
- Musculoskeletal Stiffness 285
- Insomnia 265
- Rheumatoid Arthritis 265
- Drug Hypersensitivity 254
- Injection Site Reaction 4,407
- Injection Site Pain 3,111
- Nausea 2,094
- Alcoholism 1,942
- Injection Site Mass 1,895
Cesamet can change your mental state. It has a high potential for abuse. Your doctor should watch you for signs of overuse or misuse, especially if you have a history of substance abuse or mental illness.
Naltrexone can cause serious withdrawal symptoms if you are still using opioids. Make sure you are opioid-free for at least 7 to 10 days before starting naltrexone. If you experience severe withdrawal symptoms, seek medical help right away.
The effects of Cesamet during pregnancy and breastfeeding are not well known. Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.
It is not known if naltrexone is safe to use during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if naltrexone passes into breast milk, so talk to your doctor if you are breastfeeding.
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How to Read This nabilone vs naltrexone Comparison
nabilone is classified in the Cannabinoid Antiemetic drug class, while naltrexone sits within the Opioid Antagonist class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, nabilone has 1,542 submissions while naltrexone has 13,449. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs can have a combined effect that slows down your central nervous system, leading to increased sleepiness.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for nabilone or naltrexone.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.