Naltrexone and Disulfiram Interaction
Drug interaction information between Naltrexone and Disulfiram.
Naltrexone and Disulfiram have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Naltrexone and Disulfiram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can be hard on the liver. Using them at the same time may increase your risk of developing liver problems.
FDA Label Information
The safety and efficacy of concomitant use of naltrexone hydrochloride and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.
Naltrexone Also Interacts With
- Thioridazine minor
- Acamprosate minor
- Glecaprevir/Pibrentasvir minor
- Nabilone minor
Disulfiram Also Interacts With
- Phenytoin moderate
- Acamprosate minor
- Amitriptyline minor
- Metronidazole minor
- Nabilone minor
Frequently Asked Questions
What SPL severity band is on file for Naltrexone + Disulfiram?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Disulfiram has 8 labeled pairs on file vs Naltrexone's 5. In the minor band specifically: Naltrexone has 5 (also Thioridazine, Acamprosate, Glecaprevir/Pibrentasvir, Nabilone); Disulfiram has 7 (also Acamprosate, Amitriptyline, Metronidazole, Nabilone).
What mechanism field is on file for Naltrexone and Disulfiram?
Both of these medications can be hard on the liver. Using them at the same time may increase your risk of developing liver problems.
Disulfiram's labeled portfolio outnumbers Naltrexone
SPL source-record counts only. This page's band is minor · classes on file: Naltrexone (Opioid Antagonist); Disulfiram (Aldehyde Dehydrogenase Inhibitor).
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Naltrexone
- Thioridazine
- Acamprosate
- Glecaprevir/Pibrentasvir
- Nabilone
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Disulfiram
- Acamprosate
- Amitriptyline
- Metronidazole
- Nabilone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.