Mirabegron and Rifampin Interaction
Drug interaction information between Mirabegron and Rifampin.
Mirabegron and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mirabegron and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin can speed up how your body breaks down mirabegron, which might lower the amount of medicine available to work in your system.
FDA Label Information
Drug interaction studies were conducted in adult patients to investigate the effect of coadministered drugs on the pharmacokinetics of mirabegron and the effect of mirabegron on the pharmacokinetics of coadministered drugs (e.g., ketoconazole, rifampin, solifenacin succinate, tamsulosin, and oral contraceptives) [see Clinical Pharmacology ( 12.3 )] .
Mirabegron Also Interacts With
- Tamsulosin minor
- Warfarin minor
- Ketoconazole minor
- Solifenacin minor
- Digoxin minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Mirabegron + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Mirabegron's 6. In the minor band specifically: Mirabegron has 6 (also Tamsulosin, Warfarin, Ketoconazole, Solifenacin); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Mirabegron and Rifampin?
Rifampin can speed up how your body breaks down mirabegron, which might lower the amount of medicine available to work in your system.
Rifampin carries more major-labeled pairs than Mirabegron
SPL source-record counts only. This page's band is minor · classes on file: Mirabegron (Beta-3 Agonist (Overactive Bladder)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Mirabegron's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Mirabegron
- Tamsulosin
- Warfarin
- Ketoconazole
- Solifenacin
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.