Mirabegron and Ketoconazole Interaction
Drug interaction information between Mirabegron and Ketoconazole.
Mirabegron and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mirabegron and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole can change how your body processes mirabegron, which may lead to higher levels of the medicine in your blood.
FDA Label Information
Drug interaction studies were conducted in adult patients to investigate the effect of coadministered drugs on the pharmacokinetics of mirabegron and the effect of mirabegron on the pharmacokinetics of coadministered drugs (e.g., ketoconazole, rifampin, solifenacin succinate, tamsulosin, and oral contraceptives) [see Clinical Pharmacology ( 12.3 )] .
Mirabegron Also Interacts With
- Tamsulosin minor
- Warfarin minor
- Rifampin minor
- Solifenacin minor
- Digoxin minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Mirabegron + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Mirabegron's 6. In the minor band specifically: Mirabegron has 6 (also Tamsulosin, Warfarin, Rifampin, Solifenacin); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Mirabegron and Ketoconazole?
Ketoconazole can change how your body processes mirabegron, which may lead to higher levels of the medicine in your blood.
Ketoconazole carries more major-labeled pairs than Mirabegron
SPL source-record counts only. This page's band is minor · classes on file: Mirabegron (Beta-3 Agonist (Overactive Bladder)); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Mirabegron's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Mirabegron
- Tamsulosin
- Warfarin
- Rifampin
- Solifenacin
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.