Mexiletine and Digoxin Interaction
Drug interaction information between Mexiletine and Digoxin.
Mexiletine and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mexiletine and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Mexiletine does not change the amount of digoxin in your blood or affect the heart's electrical signals when taken together.
FDA Label Information
ECG intervals (PR, QRS, and QT) were not affected by concurrent mexiletine and digoxin, diuretics, or propranolol. Mexiletine does not alter serum digoxin levels but magnesium-aluminum hydroxide, when used to treat gastrointestinal symptoms due to mexiletine, has been reported to lower serum digoxin levels.
Mexiletine Also Interacts With
- Lidocaine Topical moderate
- Propranolol minor
- Propafenone minor
- Theophylline minor
- Cimetidine minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Mexiletine + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Mexiletine's 14. In the minor band specifically: Mexiletine has 13 (also Propranolol, Propafenone, Theophylline, Cimetidine); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Mexiletine and Digoxin?
Mexiletine does not change the amount of digoxin in your blood or affect the heart's electrical signals when taken together.
Digoxin carries more major-labeled pairs than Mexiletine
SPL source-record counts only. This page's band is minor · classes on file: Mexiletine (Class IB Antiarrhythmic); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Mexiletine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Mexiletine
- Propranolol
- Propafenone
- Theophylline
- Cimetidine
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.