Mexiletine and Propranolol Interaction
Drug interaction information between Mexiletine and Propranolol.
Mexiletine and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mexiletine and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two heart medicines can be used together to help control irregular heartbeats without changing the heart's electrical timing.
FDA Label Information
A variety of antiarrhythmics such as quinidine or propranolol were also added, sometimes with improved control of ventricular ectopy. ECG intervals (PR, QRS, and QT) were not affected by concurrent mexiletine and digoxin, diuretics, or propranolol.
Mexiletine Also Interacts With
- Lidocaine Topical moderate
- Digoxin minor
- Propafenone minor
- Theophylline minor
- Cimetidine minor
Frequently Asked Questions
What SPL severity band is on file for Mexiletine + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Mexiletine's 14. In the minor band specifically: Mexiletine has 13 (also Digoxin, Propafenone, Theophylline, Cimetidine); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Mexiletine and Propranolol?
These two heart medicines can be used together to help control irregular heartbeats without changing the heart's electrical timing.
Propranolol's labeled portfolio outnumbers Mexiletine
SPL source-record counts only. This page's band is minor · classes on file: Mexiletine (Class IB Antiarrhythmic); Propranolol (Non-Selective Beta-Blocker).
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Mexiletine
- Digoxin
- Propafenone
- Theophylline
- Cimetidine
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.