Mexiletine and Propafenone Interaction
Drug interaction information between Mexiletine and Propafenone.
Mexiletine and Propafenone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mexiletine and Propafenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not appear to interfere with how the body processes either medication. They also do not cause extra changes to the heart's electrical activity when used together.
FDA Label Information
In another formal study (n = 8 extensive and n = 7 poor metabolizers of CYP2D6), coadministration of propafenone did not alter the kinetics of mexiletine in the poor CYP2D6 metabolizer group. In this crossover steady state study, the pharmacokinetics of propafenone were unaffected in either phenotype by the coadministration of mexiletine. Addition of mexiletine to propafenone did not lead to further electrocardiographic parameters changes of QRS, QT c , RR, and PR intervals than propafenone alone.
Mexiletine Also Interacts With
- Lidocaine Topical moderate
- Propranolol minor
- Digoxin minor
- Theophylline minor
- Cimetidine minor
Propafenone Also Interacts With
- Nirmatrelvir/Ritonavir major
- Amiodarone moderate
- Fluoxetine moderate
- Nebivolol moderate
- Ketoconazole minor
Frequently Asked Questions
What SPL severity band is on file for Mexiletine + Propafenone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propafenone has 26 labeled pairs on file vs Mexiletine's 14. In the minor band specifically: Mexiletine has 13 (also Propranolol, Digoxin, Theophylline, Cimetidine); Propafenone has 22 (also Ketoconazole, Erythromycin, Desipramine, Cimetidine).
What mechanism field is on file for Mexiletine and Propafenone?
These two drugs do not appear to interfere with how the body processes either medication. They also do not cause extra changes to the heart's electrical activity when used together.
Propafenone carries more major-labeled pairs than Mexiletine
SPL source-record counts only. This page's band is minor · classes on file: Mexiletine (Class IB Antiarrhythmic); Propafenone (Class IC Antiarrhythmic).
Propafenone has 1 major-labeled pair vs Mexiletine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Mexiletine
- Propranolol
- Digoxin
- Theophylline
- Cimetidine
1 major · 3 moderate · 22 minor · 26 total
- Other minor peers for Propafenone
- Ketoconazole
- Erythromycin
- Desipramine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.