darunavir vs lovastatin
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Side-by-side comparison of darunavir and lovastatin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Lipid Modifying Agents: HMG-CoA reductase inhibitors: lovastatin, simvastatin ↑ lovastatin ↑ simvastatin Co-administration is contraindicated due to potential for serious reactions such as myopathy including rhabdomyolysis.
Prezista
Mevacor, Altoprev
Darunavir is a medicine used to treat HIV. It belongs to a class of drugs called protease inhibitors and must be taken with ritonavir.
Lovastatin is a medicine that helps lower cholesterol levels in your blood. It belongs to a class of drugs called statins.
Darunavir is used to treat HIV-1 infection in adults and children 3 years and older. It must be taken with ritonavir and other HIV medicines. Darunavir helps to lower the amount of HIV in your body.
Lovastatin is used to lower cholesterol and reduce the risk of heart problems. It can help prevent heart attacks, unstable angina (chest pain), and the need for procedures to open blocked arteries. It's also used to slow down the hardening of arteries in people who already have heart disease. Lovastatin can also be used in children 10-17 years of age with high cholesterol due to genetic causes.
Darunavir is a protease inhibitor. It works by blocking an enzyme called protease that HIV needs to make copies of itself. This helps to slow down the spread of HIV in your body.
Lovastatin works by blocking a substance your body needs to make cholesterol. This helps to lower the amount of cholesterol in your blood. Lowering cholesterol helps to prevent heart disease and stroke.
- • Diarrhea
- • Nausea
- • Rash
- • Headache
- • Abdominal pain
- • Abdominal pain
- • Constipation
- • Diarrhea
- • Gas
- • Nausea
- Foetal Exposure During Pregnancy 1,150
- Drug Interaction 981
- Pain 889
- Emotional Distress 812
- Anxiety 811
- Fatigue 1,518
- Nausea 1,396
- Diarrhoea 1,251
- Dyspnoea 1,209
- Dizziness 1,147
Darunavir can cause liver problems. Your doctor should check your liver before you start taking darunavir and during treatment. Tell your doctor right away if you have any signs of liver problems, such as yellowing of the skin or eyes.
Lovastatin can cause muscle problems, including muscle breakdown (rhabdomyolysis), which can lead to kidney damage. The risk is higher if you take certain other medicines with lovastatin. You should not take lovastatin if you have liver problems or are pregnant or breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. The recommended dose during pregnancy is 600 mg twice daily with ritonavir 100mg and food. Women with HIV should not breastfeed because HIV can be passed to the baby through breast milk.
You should not take lovastatin if you are pregnant or breastfeeding. It can harm your unborn baby. If you are a woman who could become pregnant, use effective birth control while taking lovastatin.
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How to Read This darunavir vs lovastatin Comparison
darunavir is classified in the HIV Protease Inhibitor drug class, while lovastatin sits within the HMG-CoA Reductase Inhibitor (Statin) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, darunavir has 4,643 submissions while lovastatin has 6,521. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to darunavir raises the level of lovastatin in the blood, which can lead to severe muscle breakdown.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for darunavir or lovastatin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.