Liothyronine and Propranolol Interaction
Drug interaction information between Liothyronine and Propranolol.
Liothyronine and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Liothyronine and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking high doses of this blood pressure medicine can change the amount of thyroid hormones found in your blood.
FDA Label Information
Drug or Drug Class Effect Beta-adrenergic antagonists (e.g., Propranolol >160 mg/day) In patients treated with large doses of propranolol (>160 mg/day), T3 and T4 levels change, TSH levels remain normal, and patients are clinically euthyroid.
Liothyronine Also Interacts With
- Levothyroxine minor
- Sertraline minor
- Furosemide minor
- Amitriptyline minor
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Liothyronine + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Liothyronine's 17. In the minor band specifically: Liothyronine has 17 (also Levothyroxine, Sertraline, Furosemide, Amitriptyline); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Liothyronine and Propranolol?
Taking high doses of this blood pressure medicine can change the amount of thyroid hormones found in your blood.
Propranolol's labeled portfolio outnumbers Liothyronine
SPL source-record counts only. This page's band is minor · classes on file: Liothyronine (Thyroid Hormone (T3)); Propranolol (Non-Selective Beta-Blocker).
0 major · 0 moderate · 17 minor · 17 total
- Other minor peers for Liothyronine
- Levothyroxine
- Sertraline
- Furosemide
- Amitriptyline
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.