What the FDA labels say about taking them together
Amitriptyline and liothyronine
Liothyronine's FDA label of June 4, 2026 names amitriptyline in its drug interactions section; the amitriptyline label PlainMeds reads does not name liothyronine. The liothyronine label: “Concurrent use of tricyclic (e.g., amitriptyline) or tetracyclic (e.g., maprotiline) antidepressants and liothyronine sodium may increase the therapeutic and toxic effects of both drugs, possibly due to increased …”
Check it at the source: the amitriptyline FDA label on DailyMed (effective September 8, 2026, Sun Pharmaceutical Industries, Inc.); the liothyronine FDA label on DailyMed (effective June 4, 2026, Mylan Pharmaceuticals Inc.).
What does the amitriptyline label say about liothyronine?
Amitriptyline's label (effective September 8, 2026) does not name liothyronine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amitriptyline Hydrochloride), Sun Pharmaceutical Industries, Inc., effective September 8, 2026 (SPL set 4e520c63-1cf6-40f6-a51c-3f9b0e181342), via openFDA; the full label on DailyMed
What does the liothyronine label say about amitriptyline?
Liothyronine label, drug interactionsConcurrent use of tricyclic (e.g., amitriptyline) or tetracyclic (e.g., maprotiline) antidepressants and liothyronine sodium may increase the therapeutic and toxic effects of both drugs, possibly due to increased receptor sensitivity to catecholamines.
Source: FDA drug label (Liothyronine Sodium), NDA010379 (King Pharms), as published by Mylan Pharmaceuticals Inc., effective June 4, 2026 (SPL set 115a84c2-0126-4dd7-816e-1873875f1e49), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amitriptyline | Liothyronine | |
|---|---|---|
| Labeled for | Depression | Hypothyroidism |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.03 per tablet 10 mg tablet | $0.294 per tablet 25 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once