Liothyronine and Amitriptyline Interaction
Drug interaction information between Liothyronine and Amitriptyline.
Liothyronine and Amitriptyline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Liothyronine and Amitriptyline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs together can make both of them more powerful and increase the risk of side effects.
FDA Label Information
7.5 Antidepressant Therapy Concurrent use of tricyclic (e.g., amitriptyline) or tetracyclic (e.g., maprotiline) antidepressants and liothyronine sodium tablets may increase the therapeutic and toxic effects of both drugs, possibly due to increased receptor sensitivity to catecholamines.
Liothyronine Also Interacts With
- Levothyroxine minor
- Sertraline minor
- Furosemide minor
- Propranolol minor
- Carbamazepine minor
Amitriptyline Also Interacts With
- Risperidone major
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Disulfiram minor
Frequently Asked Questions
What SPL severity band is on file for Liothyronine + Amitriptyline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amitriptyline has 21 labeled pairs on file vs Liothyronine's 17. In the minor band specifically: Liothyronine has 17 (also Levothyroxine, Sertraline, Furosemide, Propranolol); Amitriptyline has 20 (also Sertraline, Fluoxetine, Paroxetine, Disulfiram).
What mechanism field is on file for Liothyronine and Amitriptyline?
Using these two drugs together can make both of them more powerful and increase the risk of side effects.
Amitriptyline carries more major-labeled pairs than Liothyronine
SPL source-record counts only. This page's band is minor · classes on file: Liothyronine (Thyroid Hormone (T3)); Amitriptyline (Tricyclic Antidepressant (TCA)).
Amitriptyline has 1 major-labeled pair vs Liothyronine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 17 minor · 17 total
- Other minor peers for Liothyronine
- Levothyroxine
- Sertraline
- Furosemide
- Propranolol
1 major · 0 moderate · 20 minor · 21 total
- Other minor peers for Amitriptyline
- Sertraline
- Fluoxetine
- Paroxetine
- Disulfiram
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.