What the FDA labels say about taking them together
Liothyronine and sertraline
Liothyronine's FDA label of June 4, 2026 names sertraline in its drug interactions section; the sertraline labels PlainMeds reads (3) do not name liothyronine. The liothyronine label: “Administration of sertraline in patients stabilized on liothyronine sodium may result in increased liothyronine sodium requirements.”
Check it at the source: the liothyronine FDA label on DailyMed (effective June 4, 2026, Mylan Pharmaceuticals Inc.); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the liothyronine label say about sertraline?
Liothyronine label, drug interactionsAdministration of sertraline in patients stabilized on liothyronine sodium may result in increased liothyronine sodium requirements.
Source: FDA drug label (Liothyronine Sodium), NDA010379 (King Pharms), as published by Mylan Pharmaceuticals Inc., effective June 4, 2026 (SPL set 115a84c2-0126-4dd7-816e-1873875f1e49), via openFDA; the full label on DailyMed
What does the sertraline label say about liothyronine?
Sertraline's label (effective August 8, 2023) and its 2 other brand-application labels do not name liothyronine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Liothyronine | Sertraline | |
|---|---|---|
| Labeled for | Hypothyroidism | Depression, Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.294 per tablet 25 mcg tablet | $0.0507 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once