Liothyronine and Sertraline Interaction
Drug interaction information between Liothyronine and Sertraline.
Liothyronine and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Liothyronine and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This antidepressant can lower the effectiveness of your thyroid medicine, meaning your body might need a higher dose.
FDA Label Information
Administration of sertraline in patients stabilized on liothyronine sodium tablets may result in increased liothyronine sodium tablets requirements.
Liothyronine Also Interacts With
- Levothyroxine minor
- Furosemide minor
- Propranolol minor
- Amitriptyline minor
- Carbamazepine minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
What SPL severity band is on file for Liothyronine + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Liothyronine's 17. In the minor band specifically: Liothyronine has 17 (also Levothyroxine, Furosemide, Propranolol, Amitriptyline); Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol).
What mechanism field is on file for Liothyronine and Sertraline?
This antidepressant can lower the effectiveness of your thyroid medicine, meaning your body might need a higher dose.
Sertraline carries more major-labeled pairs than Liothyronine
SPL source-record counts only. This page's band is minor · classes on file: Liothyronine (Thyroid Hormone (T3)); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Sertraline has 1 major-labeled pair vs Liothyronine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 17 minor · 17 total
- Other minor peers for Liothyronine
- Levothyroxine
- Furosemide
- Propranolol
- Amitriptyline
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.