Linezolid and Tranylcypromine Interaction
Drug interaction information between Linezolid and Tranylcypromine.
Linezolid and Tranylcypromine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Linezolid and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs act as MAO inhibitors, and using them together can cause a toxic buildup of chemicals in the brain. This can lead to a medical emergency with very high blood pressure.
FDA Label Information
If in the absence of therapeutic alternatives and emergency treatment with a contraindicated drug (e.g., linezolid, intravenous methylene blue, direct-acting sympathomimetic drugs such as epinephrine) becomes necessary and cannot be delayed, discontinue tranylcypromine tablets as soon as possible before initiating treatment with the other agent, and monitor closely for adverse reactions. Excessive reduction of blood glucose (additive effect) [See Warnings and Precautions (5.14)] ; CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution Increased CNS...
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Tranylcypromine Also Interacts With
- Bupropion major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
- Phenylephrine major
Frequently Asked Questions
What SPL severity band is on file for Linezolid + Tranylcypromine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Linezolid's 29. In the major band specifically: Linezolid has 8 (also Citalopram, Escitalopram, Mirtazapine, Paroxetine); Tranylcypromine has 7 (also Bupropion, Vilazodone, Epinephrine, Norepinephrine).
What mechanism field is on file for Linezolid and Tranylcypromine?
Both drugs act as MAO inhibitors, and using them together can cause a toxic buildup of chemicals in the brain. This can lead to a medical emergency with very high blood pressure.
Linezolid carries more major-labeled pairs than Tranylcypromine
SPL source-record counts only. This page's band is major · classes on file: Linezolid (Oxazolidinone Antibiotic); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Linezolid has 8 major-labeled pairs vs Tranylcypromine's 7.
8 major · 3 moderate · 18 minor · 29 total
- Other major peers for Linezolid
- Citalopram
- Escitalopram
- Mirtazapine
- Paroxetine
7 major · 23 moderate · 12 minor · 42 total
- Other major peers for Tranylcypromine
- Bupropion
- Vilazodone
- Epinephrine
- Norepinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.