linezolid vs mirtazapine
Side-by-side comparison of linezolid and mirtazapine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Intervention Mirtazapine is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [see Dosage and Administration (2.4) , Contraindications (4) , Warnings and Precautions (5.3) ]. Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact The concomitant use of serotonergic drugs with mirtazapine increases the risk of serotonin syndrome.
Recommendation: Do not take these two medications at the same time because the combination is considered unsafe and can cause a life-threatening reaction.
Zyvox
Remeron
Linezolid is an antibiotic that fights bacteria in your body. It is used to treat different types of infections.
Mirtazapine is a medicine used to treat depression in adults. It can help improve your mood and energy levels.
Linezolid treats pneumonia, skin infections, and infections caused by certain drug-resistant bacteria. It can treat pneumonia that you get in the hospital or in the community. It also treats complicated and uncomplicated skin infections, including diabetic foot infections. Linezolid can also treat infections caused by vancomycin-resistant Enterococcus faecium.
Mirtazapine is used to treat major depressive disorder (MDD) in adults. This condition can cause you to feel sad, lose interest in activities, and have trouble with sleeping or eating. Mirtazapine can help improve these symptoms.
Linezolid works by stopping the growth of bacteria. It blocks bacteria from making proteins that they need to live and multiply. This helps your body fight off the infection.
Mirtazapine works by affecting certain chemicals in the brain called neurotransmitters. It helps to increase the levels of norepinephrine and serotonin. These chemicals can help improve mood and reduce symptoms of depression.
- • Diarrhea
- • Vomiting
- • Headache
- • Nausea
- • Anemia
- • Feeling sleepy
- • Increased appetite
- • Weight gain
- • Dizziness
- Thrombocytopenia 2,032
- Anaemia 1,601
- Drug Interaction 1,381
- Nausea 1,301
- Vomiting 1,063
- Feeling sick to your stomach 4,838
- Feeling tired 4,714
- Accidentally falling down 4,026
- Loose or watery stools 3,961
- Harm from different substances 3,705
Linezolid can cause several serious side effects. It can lower your blood cell counts, so your doctor will monitor your blood. It can also cause nerve problems, especially if you take it for more than 28 days. Tell your doctor right away if you have vision changes, numbness, or tingling. Linezolid can also interact with certain antidepressants and cause a dangerous condition called serotonin syndrome. Diarrhea can also occur.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor should closely watch you for worsening depression or suicidal thoughts. Mirtazapine is not approved for use in children.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if linezolid will harm your unborn baby. It can pass into breast milk, so talk to your doctor about breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Mirtazapine should be used during pregnancy only if clearly needed. Talk to your doctor if you are breastfeeding.
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How to Read This linezolid vs mirtazapine Comparison
linezolid is classified in the Oxazolidinone Antibiotic drug class, while mirtazapine sits within the Noradrenergic and Specific Serotonergic Antidepressant (NaSSA) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, linezolid has 7,378 submissions while mirtazapine has 21,244. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to linezolid blocks the breakdown of a brain chemical called serotonin, and adding mirtazapine can cause levels to become dangerously high.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between linezolid and mirtazapine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.