Empagliflozin/Linagliptin and Rifampin Interaction
Drug interaction information between Empagliflozin/Linagliptin and Rifampin.
Empagliflozin/Linagliptin and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Empagliflozin/Linagliptin and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin makes your body process the diabetes medicine much faster than normal. This can prevent the medicine from staying in your system long enough to control your blood sugar.
FDA Label Information
Inducers of P-glycoprotein or CYP3A4 Enzymes Clinical Impact Rifampin decreased linagliptin exposure, suggesting that the efficacy of linagliptin may be reduced when administered in combination with a strong P-gp or CYP3A4 inducer.
Empagliflozin/Linagliptin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Empagliflozin minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Empagliflozin/Linagliptin + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Empagliflozin/Linagliptin's 11. In the minor band specifically: Empagliflozin/Linagliptin has 7 (also Empagliflozin, Topiramate, Lithium, Linagliptin); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Empagliflozin/Linagliptin and Rifampin?
Rifampin makes your body process the diabetes medicine much faster than normal. This can prevent the medicine from staying in your system long enough to control your blood sugar.
Rifampin carries more major-labeled pairs than Empagliflozin/Linagliptin
SPL source-record counts only. This page's band is minor · classes on file: Empagliflozin/Linagliptin (SGLT2 / DPP-4 Combination); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Empagliflozin/Linagliptin's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Empagliflozin/Linagliptin
- Empagliflozin
- Topiramate
- Lithium
- Linagliptin
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.