Empagliflozin/Linagliptin and Lithium Interaction
Drug interaction information between Empagliflozin/Linagliptin and Lithium.
Empagliflozin/Linagliptin and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Empagliflozin/Linagliptin and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This diabetes medicine can cause your kidneys to remove lithium from your body more quickly. This may lower the amount of lithium in your blood and make it work less effectively.
FDA Label Information
Lithium Clinical Impact Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention Monitor serum lithium concentration more frequently during TRIJARDY XR initiation and dosage changes.
Empagliflozin/Linagliptin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Empagliflozin minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Empagliflozin/Linagliptin + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Empagliflozin/Linagliptin's 11. In the minor band specifically: Empagliflozin/Linagliptin has 7 (also Empagliflozin, Topiramate, Rifampin, Linagliptin); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Empagliflozin/Linagliptin and Lithium?
This diabetes medicine can cause your kidneys to remove lithium from your body more quickly. This may lower the amount of lithium in your blood and make it work less effectively.
Lithium carries more major-labeled pairs than Empagliflozin/Linagliptin
SPL source-record counts only. This page's band is minor · classes on file: Empagliflozin/Linagliptin (SGLT2 / DPP-4 Combination); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Empagliflozin/Linagliptin's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Empagliflozin/Linagliptin
- Empagliflozin
- Topiramate
- Rifampin
- Linagliptin
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.