Empagliflozin/Linagliptin and Topiramate Interaction
Drug interaction information between Empagliflozin/Linagliptin and Topiramate.
Empagliflozin/Linagliptin and Topiramate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Empagliflozin/Linagliptin and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Topiramate can lower the levels of certain chemicals that keep your blood from becoming too acidic. This can lead to a dangerous acid buildup in the body.
Empagliflozin/Linagliptin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Empagliflozin minor
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Empagliflozin/Linagliptin + Topiramate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Topiramate has 30 labeled pairs on file vs Empagliflozin/Linagliptin's 11. In the minor band specifically: Empagliflozin/Linagliptin has 7 (also Empagliflozin, Lithium, Rifampin, Linagliptin); Topiramate has 27 (also Hydrochlorothiazide, Amitriptyline, Pioglitazone, Carbamazepine).
What mechanism field is on file for Empagliflozin/Linagliptin and Topiramate?
Topiramate can lower the levels of certain chemicals that keep your blood from becoming too acidic. This can lead to a dangerous acid buildup in the body.
Topiramate's labeled portfolio outnumbers Empagliflozin/Linagliptin
SPL source-record counts only. This page's band is minor · classes on file: Empagliflozin/Linagliptin (SGLT2 / DPP-4 Combination); Topiramate (Anticonvulsant).
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Empagliflozin/Linagliptin
- Empagliflozin
- Lithium
- Rifampin
- Linagliptin
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Hydrochlorothiazide
- Amitriptyline
- Pioglitazone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.