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aspirin vs levomilnacipran

Side-by-side comparison of aspirin and levomilnacipran. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

minor Known Drug Interaction

Examples: NSAIDs, aspirin, and warfarin Strong CYP3A4 Inhibitors Clinical Impact: Concomitant use of FETZIMA with strong CYP3A4 inhibitors increases levomilnacipran exposure [see Pharmacokinetics ( 12.3 )] .

Recommendation: Watch for signs of bleeding, such as easy bruising or dark stools. Your doctor may need to check your health more often if you take both.

Drug Class
aspirin Antiplatelet / NSAID
levomilnacipran Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
Type
aspirin Over-the-Counter
levomilnacipran Prescription
Summary
aspirin

Aspirin is a common medicine used to relieve minor pain. It can also be prescribed by your doctor for other uses.

levomilnacipran

Fetzima is a medicine used to treat major depressive disorder (MDD) in adults. It helps to improve your mood by affecting certain chemicals in the brain.

What It Treats
aspirin

Aspirin is used to temporarily relieve minor aches and pains. However, it works slowly. It will not quickly relieve headaches or other symptoms that need immediate relief. Ask your doctor about other uses for this medicine.

levomilnacipran

Fetzima is used to treat major depressive disorder (MDD) in adults. MDD can cause you to feel sad, lose interest in activities, and have trouble with daily life. Fetzima can help improve your mood and reduce these symptoms.

How It Works
aspirin

Aspirin belongs to a class of drugs called NSAIDs and antiplatelets. It works by reducing substances in the body that cause pain and inflammation. It also helps to prevent blood clots.

levomilnacipran

Fetzima is a type of drug called a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by increasing the levels of serotonin and norepinephrine in your brain. These chemicals can help improve your mood and reduce symptoms of depression.

Common Side Effects
aspirin
  • Upset stomach
  • Heartburn
levomilnacipran
  • Nausea
  • Constipation
  • Increased sweating
  • Increased heart rate
  • Erectile dysfunction
FAERS Reports
aspirin
  • Tiredness 31,969
  • Shortness of breath 27,184
  • Feeling sick to your stomach 26,582
  • Loose stools 26,451
  • Feeling lightheaded 22,392
levomilnacipran
  • Pain 210
  • Throwing up 208
  • Trouble remembering things 189
  • Numbness or tingling 179
  • Reduced sense of touch 178
Serious Warnings
aspirin

No specific warnings noted.

levomilnacipran

Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor should closely watch you for worsening depression or suicidal thoughts. Fetzima is not approved for use in children.

Pregnancy
aspirin

Ask your doctor for advice if you are pregnant or breastfeeding.

levomilnacipran

Tell your doctor if you are pregnant or plan to become pregnant. Using Fetzima in the last months of pregnancy may cause problems in the newborn. There is a pregnancy registry for women who take antidepressants during pregnancy.

Also Compare, Nearby Drugs

How to Read This aspirin vs levomilnacipran Comparison

aspirin is classified in the Antiplatelet / NSAID drug class, while levomilnacipran sits within the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aspirin has 134,578 submissions while levomilnacipran has 964. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these medicines can both interfere with how your blood forms clots. using them together increases your risk of having problems with bleeding or bruising.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between aspirin and levomilnacipran - always consult your physician or pharmacist first.

Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.