cyclosporine vs levofloxacin
Side-by-side comparison of cyclosporine and levofloxacin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.6 Cyclosporine No significant effect of levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for cyclosporine was detected in a clinical study involving healthy volunteers. However, elevated serum levels of cyclosporine have been reported in the patient population when co-administered with some other fluoroquinolones. Levofloxacin C max and k e were slightly lower while T max and t1/2 were slightly longer in the presence of cyclosporine than those observed in other studies without concomitant medication.
Recommendation: Your doctor may need to monitor your cyclosporine blood levels to ensure they stay in a safe range.
Neoral, Sandimmune, Restasis
Levaquin
Vevye eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
Levofloxacin is an antibiotic that fights bacteria in your body. It is used to treat different types of infections.
Vevye treats the signs and symptoms of dry eye disease. Dry eye can cause discomfort, stinging, and blurred vision. This medicine can help reduce these symptoms.
Levofloxacin treats infections like pneumonia, skin infections, prostate infections, and urinary tract infections. It can also treat anthrax after exposure and plague. This medicine should only be used for certain infections when other options won't work.
Vevye contains cyclosporine, which is an immunosuppressant. It works by decreasing inflammation in the eyes. This helps your eyes make more tears.
Levofloxacin belongs to a class of drugs called fluoroquinolones. It works by stopping bacteria from multiplying. This helps your body fight off the infection.
- • Irritation where the drops are applied (8%)
- • Nausea
- • Headache
- • Diarrhea
- • Trouble sleeping
- • Constipation
- Eye feels irritated 7,786
- Fever 4,066
- Eye ache 3,808
- Feeling sick to your stomach 3,623
- Loose stools 3,562
- Dyspnoea 2,949
- Pneumonia 2,862
- Nausea 2,791
- Pyrexia 2,725
- Fatigue 2,658
To avoid eye injury or contamination, do not touch the bottle tip to your eye or any other surface. Do not use Vevye while wearing contact lenses. If you wear contacts, remove them before using the drops. You can put them back in 15 minutes after using Vevye.
This drug has serious warnings. Levofloxacin can cause tendon problems, nerve damage, and central nervous system effects. It can also make muscle weakness worse if you have myasthenia gravis. If you have any of these side effects, stop taking the medicine and call your doctor right away. Only use this medicine if you have no other treatment options for uncomplicated urinary tract infections, bronchitis, or sinusitis.
It is not known if Vevye will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Cyclosporine can pass into breast milk after being taken orally, but it is unknown if it passes into breast milk from eye drops. Talk to your doctor if you are breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Levofloxacin should only be used during pregnancy if the benefit outweighs the risk to the baby. It may pass into breast milk, so talk to your doctor about breastfeeding.
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How to Read This cyclosporine vs levofloxacin Comparison
cyclosporine is classified in the Calcineurin Inhibitor (Immunosuppressant) drug class, while levofloxacin sits within the Fluoroquinolone Antibiotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cyclosporine has 22,845 submissions while levofloxacin has 13,985. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to levofloxacin may slightly change how your body processes cyclosporine, and similar drugs have been known to raise cyclosporine levels in the blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between cyclosporine and levofloxacin - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.