Insulin Glargine and Clonidine Interaction
Drug interaction information between Insulin Glargine and Clonidine.
Insulin Glargine and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Glargine and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clonidine can cause blood sugar to go up or down and can also hide the physical signs that your blood sugar is too low.
FDA Label Information
Drugs That May Increase or Decrease the Blood Glucose Lowering Effect of BASAGLAR Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Drugs That May Blunt Signs and Symptoms of Hypoglycemia Drugs: beta-blockers, clonidine, guanethidine, and reserpine Intervention: Increased frequency of glucose monitoring may be required when BASAGLAR is co-administered with these drugs. Drugs that may increase or decrease the blood glucose lowering effect: alcohol, beta-blockers, clonidine, lithium salts, and pentamidine ( 7 ).
Insulin Glargine Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Olanzapine minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Glargine + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Insulin Glargine's 11. In the minor band specifically: Insulin Glargine has 8 (also Albuterol, Olanzapine, Lithium, Clozapine); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Insulin Glargine and Clonidine?
Clonidine can cause blood sugar to go up or down and can also hide the physical signs that your blood sugar is too low.
Clonidine's labeled portfolio outnumbers Insulin Glargine
SPL source-record counts only. This page's band is minor · classes on file: Insulin Glargine (Long-Acting Insulin); Clonidine (Central Alpha-2 Agonist).
0 major · 3 moderate · 8 minor · 11 total
- Other minor peers for Insulin Glargine
- Albuterol
- Olanzapine
- Lithium
- Clozapine
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.