Insulin Glargine and Fluoxetine Interaction
Drug interaction information between Insulin Glargine and Fluoxetine.
Insulin Glargine and Fluoxetine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Glargine and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine can increase the effect of insulin, which may cause your blood sugar to drop lower than expected.
FDA Label Information
7 DRUG INTERACTIONS Table 6 includes clinically significant drug interactions with BASAGLAR Table 6: Clinically Significant Drug Interactions with BASAGLAR Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents,...
Insulin Glargine Also Interacts With
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
- Olanzapine minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Insulin Glargine + Fluoxetine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Insulin Glargine's 11. In the moderate band specifically: Insulin Glargine has 3 (also Pramlintide, Octreotide); Fluoxetine has 19 (also Alprazolam, Diazepam, Carbamazepine, Haloperidol).
What mechanism field is on file for Insulin Glargine and Fluoxetine?
Fluoxetine can increase the effect of insulin, which may cause your blood sugar to drop lower than expected.
Fluoxetine carries more major-labeled pairs than Insulin Glargine
SPL source-record counts only. This page's band is moderate · classes on file: Insulin Glargine (Long-Acting Insulin); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Insulin Glargine's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 8 minor · 11 total
- Other moderate peers for Insulin Glargine
- Pramlintide
- Octreotide
6 major · 19 moderate · 43 minor · 68 total
- Other moderate peers for Fluoxetine
- Alprazolam
- Diazepam
- Carbamazepine
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.