Insulin Glargine and Octreotide Interaction
Drug interaction information between Insulin Glargine and Octreotide.
Insulin Glargine and Octreotide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Glargine and Octreotide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Octreotide can lower blood sugar levels, which adds to the effect of insulin and increases the risk of a dangerous drop.
FDA Label Information
7 DRUG INTERACTIONS Table 6 includes clinically significant drug interactions with BASAGLAR Table 6: Clinically Significant Drug Interactions with BASAGLAR Drugs That May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analogs (e.g., octreotide), and sulfonamide antibiotics. Drugs that may increase the risk of hypoglycemia: antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents,...
Insulin Glargine Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Albuterol minor
- Clonidine minor
- Olanzapine minor
Octreotide Also Interacts With
- Insulin Aspart moderate
- Insulin Degludec moderate
- Insulin Detemir moderate
- Insulin Glulisine moderate
- Insulin Human/Insulin Isophane moderate
Frequently Asked Questions
What SPL severity band is on file for Insulin Glargine + Octreotide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Octreotide has 14 labeled pairs on file vs Insulin Glargine's 11. In the moderate band specifically: Insulin Glargine has 3 (also Fluoxetine, Pramlintide); Octreotide has 9 (also Insulin Aspart, Insulin Degludec, Insulin Detemir, Insulin Glulisine).
What mechanism field is on file for Insulin Glargine and Octreotide?
Octreotide can lower blood sugar levels, which adds to the effect of insulin and increases the risk of a dangerous drop.
Octreotide's labeled portfolio outnumbers Insulin Glargine
SPL source-record counts only. This page's band is moderate · classes on file: Insulin Glargine (Long-Acting Insulin); Octreotide (Somatostatin Analog).
0 major · 3 moderate · 8 minor · 11 total
- Other moderate peers for Insulin Glargine
- Fluoxetine
- Pramlintide
0 major · 9 moderate · 5 minor · 14 total
- Other moderate peers for Octreotide
- Insulin Aspart
- Insulin Degludec
- Insulin Detemir
- Insulin Glulisine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.