Insulin Glargine and Olanzapine Interaction
Drug interaction information between Insulin Glargine and Olanzapine.
Insulin Glargine and Olanzapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Glargine and Olanzapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Olanzapine can reduce the blood-sugar-lowering power of insulin, which may lead to higher blood sugar readings.
FDA Label Information
Drugs That May Decrease the Blood Glucose Lowering Effect of BASAGLAR Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones Intervention: Dose increases and increased frequency of glucose monitoring may be required when BASAGLAR is co-administered with these drugs.
Insulin Glargine Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Olanzapine Also Interacts With
- Fluoxetine major
- Tetrabenazine moderate
- Omeprazole minor
- Warfarin minor
- Diazepam minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Glargine + Olanzapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Olanzapine has 26 labeled pairs on file vs Insulin Glargine's 11. In the minor band specifically: Insulin Glargine has 8 (also Albuterol, Clonidine, Lithium, Clozapine); Olanzapine has 24 (also Omeprazole, Warfarin, Diazepam, Carbamazepine).
What mechanism field is on file for Insulin Glargine and Olanzapine?
Olanzapine can reduce the blood-sugar-lowering power of insulin, which may lead to higher blood sugar readings.
Olanzapine carries more major-labeled pairs than Insulin Glargine
SPL source-record counts only. This page's band is minor · classes on file: Insulin Glargine (Long-Acting Insulin); Olanzapine (Atypical Antipsychotic).
Olanzapine has 1 major-labeled pair vs Insulin Glargine's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 8 minor · 11 total
1 major · 1 moderate · 24 minor · 26 total
- Other minor peers for Olanzapine
- Omeprazole
- Warfarin
- Diazepam
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.