Pramlintide and Insulin Human Interaction
Drug interaction information between Pramlintide and Insulin Human.
Pramlintide and Insulin Human have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pramlintide and Insulin Human. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Pramlintide can increase the risk of low blood sugar when taken with insulin.
FDA Label Information
7 DRUG INTERACTIONS Table 1: Clinically Significant Drug Interactions with HUMULIN 70/30 Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics Intervention: Dose adjustment and increased frequency of glucose monitoring may be required when HUMULIN 70/30 is co-administered with these drugs.
Pramlintide Also Interacts With
- Insulin Aspart moderate
- Insulin Degludec moderate
- Insulin Detemir moderate
- Insulin Glargine moderate
- Insulin Glulisine moderate
Insulin Human Also Interacts With
- Fluoxetine moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
- Olanzapine minor
Frequently Asked Questions
What SPL severity band is on file for Pramlintide + Insulin Human/Insulin Isophane?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pramlintide has 13 labeled pairs on file vs Insulin Human's 11. In the moderate band specifically: Pramlintide has 9 (also Insulin Aspart, Insulin Degludec, Insulin Detemir, Insulin Glargine); Insulin Human has 3 (also Fluoxetine, Octreotide).
What mechanism field is on file for Pramlintide and Insulin Human/Insulin Isophane?
Pramlintide can increase the risk of low blood sugar when taken with insulin.
Pramlintide's labeled portfolio outnumbers Insulin Human
SPL source-record counts only. This page's band is moderate · classes on file: Pramlintide (Amylin Analog); Insulin Human (Intermediate-Acting Insulin Combination).
0 major · 9 moderate · 4 minor · 13 total
- Other moderate peers for Pramlintide
- Insulin Aspart
- Insulin Degludec
- Insulin Detemir
- Insulin Glargine
0 major · 3 moderate · 8 minor · 11 total
- Other moderate peers for Insulin Human
- Fluoxetine
- Octreotide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.