Infliximab and Folic Acid Interaction
Drug interaction information between Infliximab and Folic Acid.
Infliximab and Folic Acid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Infliximab and Folic Acid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is no known negative interaction between these two drugs, and they are frequently used together to manage rheumatoid arthritis.
FDA Label Information
In RA, concomitant medications besides MTX were nonsteroidal anti-inflammatory agents (NSAIDs), folic acid, corticosteroids and/or narcotics. In PsA clinical trials, concomitant medications included MTX in approximately half of the patients as well as NSAIDs, folic acid and corticosteroids.
Infliximab Also Interacts With
- Abatacept moderate
- Warfarin minor
- Methotrexate minor
- Ciprofloxacin minor
- Cyclosporine minor
Folic Acid Also Interacts With
- Dapsone Topical minor
- Methotrexate minor
- Phenytoin minor
- Prenatal Multivitamin minor
Frequently Asked Questions
What SPL severity band is on file for Infliximab + Folic Acid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Infliximab has 8 labeled pairs on file vs Folic Acid's 5. In the minor band specifically: Infliximab has 7 (also Warfarin, Methotrexate, Ciprofloxacin, Cyclosporine); Folic Acid has 5 (also Dapsone Topical, Methotrexate, Phenytoin, Prenatal Multivitamin).
What mechanism field is on file for Infliximab and Folic Acid?
There is no known negative interaction between these two drugs, and they are frequently used together to manage rheumatoid arthritis.
Infliximab's labeled portfolio outnumbers Folic Acid
SPL source-record counts only. This page's band is minor · classes on file: Infliximab (TNF-Alpha Inhibitor (Biologic)); Folic Acid (B Vitamin (Folate) Supplement).
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Infliximab
- Warfarin
- Methotrexate
- Ciprofloxacin
- Cyclosporine
0 major · 0 moderate · 5 minor · 5 total
- Other minor peers for Folic Acid
- Dapsone Topical
- Methotrexate
- Phenytoin
- Prenatal Multivitamin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.