Infliximab and Cyclosporine Interaction
Drug interaction information between Infliximab and Cyclosporine.
Infliximab and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Infliximab and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Infliximab may affect the liver enzymes that process cyclosporine, which could change the amount of medicine in your system.
FDA Label Information
Upon initiation or discontinuation of INFLECTRA in patients being treated with CYP450 substrates with a narrow therapeutic index, monitoring of the effect (e.g., warfarin) or drug concentration (e.g., cyclosporine or theophylline) is recommended and the individual dose of the drug product may be adjusted as needed.
Infliximab Also Interacts With
- Abatacept moderate
- Folic Acid minor
- Warfarin minor
- Methotrexate minor
- Ciprofloxacin minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Infliximab + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Infliximab's 8. In the minor band specifically: Infliximab has 7 (also Folic Acid, Warfarin, Methotrexate, Ciprofloxacin); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Infliximab and Cyclosporine?
Infliximab may affect the liver enzymes that process cyclosporine, which could change the amount of medicine in your system.
Cyclosporine carries more major-labeled pairs than Infliximab
SPL source-record counts only. This page's band is minor · classes on file: Infliximab (TNF-Alpha Inhibitor (Biologic)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Infliximab's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Infliximab
- Folic Acid
- Warfarin
- Methotrexate
- Ciprofloxacin
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.